Assay Detail
Binding
CHEMBL644830
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Concentration required to inhibit acetylcholinesterase isolated from human erythrocytes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Total synthesis of an optically active 8-carba-physostigmine analog: a potent acetylcholinesterase inhibitor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.07 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL413765 | — | — | 1 | 7.70 |
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 6.89 |
| CHEMBL359198 | — | — | 1 | 6.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL413765 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL359198 | — | IC50 | = | 233.0 | nM | 6.63 |