Assay Detail
Binding
CHEMBL644833
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In vitro inhibition of human acetylcholinesterase.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and cholinergic properties of N-aryl-2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethylamino analogs of ranitidine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.48 | 7.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 7.37 |
| CHEMBL321605 | — | — | 1 | 7.12 |
| CHEMBL107892 | — | — | 1 | 7.08 |
| CHEMBL104681 | — | — | 1 | 6.92 |
| CHEMBL320291 | — | — | 1 | 6.80 |
| CHEMBL316973 | — | — | 1 | 6.70 |
| CHEMBL106782 | — | — | 1 | 6.58 |
| CHEMBL327135 | — | — | 1 | 6.57 |
| CHEMBL107673 | — | — | 1 | 6.51 |
| CHEMBL318517 | — | — | 1 | 6.43 |
| CHEMBL106932 | — | — | 1 | 6.36 |
| CHEMBL106348 | — | — | 1 | 6.28 |
| CHEMBL106082 | — | — | 1 | 6.20 |
| CHEMBL104334 | — | — | 1 | 6.19 |
| CHEMBL108163 | — | — | 1 | 6.19 |
| CHEMBL104355 | — | — | 1 | 6.19 |
| CHEMBL107254 | — | — | 1 | 6.17 |
| CHEMBL106936 | — | — | 1 | 6.16 |
| CHEMBL106418 | — | — | 1 | 5.92 |
| CHEMBL106344 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL321605 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL107892 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL104681 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL320291 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL316973 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL106782 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL327135 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL107673 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL318517 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL106932 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL106348 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL106082 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL104334 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL108163 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL104355 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL107254 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL106936 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL106418 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL106344 | — | IC50 | = | 1300.0 | nM | 5.89 |