Assay Detail
Binding
CHEMBL644837
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In vitro inhibition of Acetylcholinesterase from human erythrocytes
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
5,7-dihydro-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-6H- pyrrolo[3,2-f]-1,2-benzisoxazol-6-one: a potent and centrally-selective inhibitor of acetylcholinesterase with an improved margin of safety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.69 | 9.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL329012 | ICOPEZIL MALEATE | 2.0 | 1 | 9.48 |
| CHEMBL94546 | — | — | 1 | 9.32 |
| CHEMBL329231 | — | — | 1 | 9.24 |
| CHEMBL328468 | — | — | 1 | 9.02 |
| CHEMBL94217 | — | — | 1 | 8.55 |
| CHEMBL95020 | — | — | 1 | 8.44 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL329012 | ICOPEZIL MALEATE | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL94546 | — | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL329231 | — | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL328468 | — | IC50 | = | 0.95 | nM | 9.02 |
| CHEMBL94217 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL95020 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL95 | TACRINE | IC50 | = | 170.0 | nM | 6.77 |