Assay Detail
Binding
CHEMBL644838
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of acetylcholinesterase (AChE) of human red blood cell (type XIII) by modified radiometric AChE assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
The synthesis and in vitro acetylcholinesterase and butyrylcholinesterase inhibitory activity of tacrine (Cognex) derivaties
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.42 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL292314 | — | — | 1 | 8.74 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 8.63 |
| CHEMBL352500 | — | — | 1 | 8.35 |
| CHEMBL134057 | — | — | 1 | 8.03 |
| CHEMBL431844 | — | — | 1 | 7.50 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.47 |
| CHEMBL368196 | — | — | 1 | 7.38 |
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 7.21 |
| CHEMBL369661 | — | — | 1 | 7.16 |
| CHEMBL355740 | — | — | 1 | 7.07 |
| CHEMBL51934 | VELNACRINE | 2.0 | 1 | 6.79 |
| CHEMBL62084 | — | — | 1 | 6.13 |
| CHEMBL172118 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL292314 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 2.33 | nM | 8.63 |
| CHEMBL352500 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL134057 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL431844 | — | IC50 | = | 31.5 | nM | 7.50 |
| CHEMBL95 | TACRINE | IC50 | = | 33.5 | nM | 7.47 |
| CHEMBL368196 | — | IC50 | = | 42.2 | nM | 7.38 |
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL369661 | — | IC50 | = | 68.9 | nM | 7.16 |
| CHEMBL355740 | — | IC50 | = | 84.3 | nM | 7.07 |
| CHEMBL51934 | VELNACRINE | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL62084 | — | IC50 | = | 743.0 | nM | 6.13 |
| CHEMBL172118 | — | IC50 | = | 1100.0 | nM | 5.96 |