Assay Detail
Binding
CHEMBL644954
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In vitro binding affinity at Alpha-1 adrenergic receptor in rat cortical tissues
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
New pyridobenzodiazepine derivatives: modifications of the basic side chain differentially modulate binding to dopamine (D(4.2), D(2L)) and serotonin (5-HT(2A)) receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 7.17 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.89 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.85 |
| CHEMBL347959 | — | — | 1 | 7.75 |
| CHEMBL357391 | — | — | 1 | 7.20 |
| CHEMBL63576 | — | — | 1 | 7.10 |
| CHEMBL358657 | — | — | 1 | 7.00 |
| CHEMBL63329 | — | — | 1 | 6.97 |
| CHEMBL342536 | — | — | 1 | 6.79 |
| CHEMBL422310 | — | — | 1 | 6.76 |
| CHEMBL436274 | — | — | 1 | 6.43 |
| CHEMBL423760 | — | — | 1 | - |
| CHEMBL146856 | — | — | 1 | - |
| CHEMBL148042 | — | — | 1 | - |
| CHEMBL148965 | — | — | 1 | - |
| CHEMBL149949 | — | — | 1 | - |
| CHEMBL357320 | — | — | 1 | - |
| CHEMBL347292 | — | — | 1 | - |
| CHEMBL345964 | — | — | 1 | - |
| CHEMBL148836 | — | — | 1 | - |
| CHEMBL424314 | — | — | 1 | - |
| CHEMBL147473 | — | — | 1 | - |
| CHEMBL149493 | — | — | 1 | - |
| CHEMBL148952 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL42 | CLOZAPINE | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL347959 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL357391 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL63576 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL358657 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL63329 | — | Ki | = | 108.0 | nM | 6.97 |
| CHEMBL342536 | — | Ki | = | 163.0 | nM | 6.79 |
| CHEMBL422310 | — | Ki | = | 172.0 | nM | 6.76 |
| CHEMBL436274 | — | Ki | = | 367.0 | nM | 6.43 |
| CHEMBL423760 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL146856 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL148042 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL148965 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL149949 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL357320 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL347292 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL345964 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL148836 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL424314 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL147473 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL149493 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL148952 | — | Ki | > | 1000.0 | nM | - |