Assay Detail
Binding
CHEMBL644960
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity towards Alpha-1 adrenergic receptor by the displacement of [3H]prazosin radioligand in rat cortical homogenates
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
New generation dopaminergic agents. 6. Structure-activity relationship studies of a series of 4-(aminoethoxy)indole and 4-(aminoethoxy)indolone derivatives based on the newly discovered 3-hydroxyphenoxyethylamine D2 template.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 6.75 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL60548 | — | — | 1 | 8.30 |
| CHEMBL64466 | — | — | 1 | 7.85 |
| CHEMBL60185 | — | — | 1 | 7.62 |
| CHEMBL64574 | — | — | 1 | 7.50 |
| CHEMBL418510 | — | — | 1 | 7.41 |
| CHEMBL63491 | — | — | 1 | 7.28 |
| CHEMBL64524 | — | — | 1 | 7.07 |
| CHEMBL291459 | — | — | 1 | 6.89 |
| CHEMBL302000 | — | — | 1 | 6.87 |
| CHEMBL64553 | — | — | 1 | 6.67 |
| CHEMBL64798 | — | — | 1 | 6.66 |
| CHEMBL300571 | — | — | 1 | 6.59 |
| CHEMBL59750 | — | — | 1 | 6.42 |
| CHEMBL59752 | — | — | 1 | 5.84 |
| CHEMBL418681 | — | — | 1 | 5.54 |
| CHEMBL434407 | — | — | 1 | 5.32 |
| CHEMBL416856 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL60548 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL64466 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL60185 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL64574 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL418510 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL63491 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL64524 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL291459 | — | Ki | = | 128.0 | nM | 6.89 |
| CHEMBL302000 | — | Ki | = | 134.0 | nM | 6.87 |
| CHEMBL64553 | — | Ki | = | 212.0 | nM | 6.67 |
| CHEMBL64798 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL300571 | — | Ki | = | 254.0 | nM | 6.59 |
| CHEMBL59750 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL59752 | — | Ki | = | 1448.0 | nM | 5.84 |
| CHEMBL418681 | — | Ki | = | 2899.0 | nM | 5.54 |
| CHEMBL434407 | — | Ki | = | 4829.0 | nM | 5.32 |
| CHEMBL416856 | — | Ki | = | 11081.0 | nM | 4.96 |