Assay Detail
Binding
CHEMBL644963
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity towards alpha-1 adrenergic receptor by the displacement of [3H]prazosin radioligand in rat cortical homogenates
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
New generation dopaminergic agents. 6. Structure-activity relationship studies of a series of 4-(aminoethoxy)indole and 4-(aminoethoxy)indolone derivatives based on the newly discovered 3-hydroxyphenoxyethylamine D2 template.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 6.94 | 8.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64420 | — | — | 1 | 8.07 |
| CHEMBL60900 | — | — | 1 | 8.02 |
| CHEMBL304894 | — | — | 1 | 7.96 |
| CHEMBL59737 | — | — | 1 | 7.94 |
| CHEMBL61671 | — | — | 1 | 7.89 |
| CHEMBL302436 | — | — | 1 | 7.60 |
| CHEMBL60265 | — | — | 1 | 7.58 |
| CHEMBL59501 | — | — | 1 | 7.39 |
| CHEMBL60783 | — | — | 1 | 7.22 |
| CHEMBL294204 | — | — | 1 | 7.18 |
| CHEMBL60840 | — | — | 1 | 7.01 |
| CHEMBL64134 | — | — | 1 | 6.86 |
| CHEMBL292253 | — | — | 1 | 6.84 |
| CHEMBL62290 | — | — | 1 | 6.81 |
| CHEMBL303556 | — | — | 1 | 6.78 |
| CHEMBL64345 | — | — | 1 | 6.64 |
| CHEMBL300316 | — | — | 1 | 6.57 |
| CHEMBL61665 | — | — | 1 | 6.57 |
| CHEMBL294538 | — | — | 1 | 6.54 |
| CHEMBL305585 | — | — | 1 | 6.48 |
| CHEMBL435182 | — | — | 1 | 6.46 |
| CHEMBL59500 | — | — | 1 | 6.37 |
| CHEMBL60361 | — | — | 1 | 6.34 |
| CHEMBL64283 | — | — | 1 | 6.17 |
| CHEMBL64238 | — | — | 1 | 5.98 |
| CHEMBL64508 | — | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64420 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL60900 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL304894 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL59737 | — | Ki | = | 11.5 | nM | 7.94 |
| CHEMBL61671 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL302436 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL60265 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL59501 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL60783 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL294204 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL60840 | — | Ki | = | 97.5 | nM | 7.01 |
| CHEMBL64134 | — | Ki | = | 138.5 | nM | 6.86 |
| CHEMBL292253 | — | Ki | = | 143.0 | nM | 6.84 |
| CHEMBL62290 | — | Ki | = | 154.0 | nM | 6.81 |
| CHEMBL303556 | — | Ki | = | 165.0 | nM | 6.78 |
| CHEMBL64345 | — | Ki | = | 229.0 | nM | 6.64 |
| CHEMBL300316 | — | Ki | = | 268.0 | nM | 6.57 |
| CHEMBL61665 | — | Ki | = | 268.0 | nM | 6.57 |
| CHEMBL294538 | — | Ki | = | 292.0 | nM | 6.54 |
| CHEMBL305585 | — | Ki | = | 334.0 | nM | 6.48 |
| CHEMBL435182 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL59500 | — | Ki | = | 431.0 | nM | 6.37 |
| CHEMBL60361 | — | Ki | = | 458.0 | nM | 6.34 |
| CHEMBL64283 | — | Ki | = | 675.0 | nM | 6.17 |
| CHEMBL64238 | — | Ki | = | 1057.0 | nM | 5.98 |
| CHEMBL64508 | — | Ki | = | 5291.0 | nM | 5.28 |