Assay Detail
Binding
CHEMBL645001
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Inhibition of Acetylcholinesterase (AChE) from human RBC
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of new acetylcholinesterase inhibitors: Morpholinoalkylcarbamoyloxyeseroline derivatives
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.50 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 7.52 |
| CHEMBL431519 | — | — | 1 | 7.40 |
| CHEMBL62664 | — | — | 1 | 7.40 |
| CHEMBL64011 | — | — | 1 | 7.22 |
| CHEMBL65585 | — | — | 1 | 7.16 |
| CHEMBL65018 | — | — | 1 | 7.10 |
| CHEMBL433041 | EPTASTIGMINE | 2.0 | 1 | 6.54 |
| CHEMBL66309 | — | — | 1 | 6.42 |
| CHEMBL65356 | — | — | 1 | 6.03 |
| CHEMBL65667 | — | — | 1 | 5.42 |
| CHEMBL303574 | — | — | 1 | 5.12 |
| CHEMBL63173 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL431519 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL62664 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL64011 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL65585 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL65018 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL433041 | EPTASTIGMINE | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL66309 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL65356 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL65667 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL303574 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL63173 | — | IC50 | = | 21000.0 | nM | 4.68 |