Assay Detail
Functional
CHEMBL645002
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In vitro inhibitory activity against human acetylcholinesterase
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Syntheses and anticholinesterase activity of tetrahydrobenzazepine carbamates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.94 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL413765 | — | — | 1 | 7.70 |
| CHEMBL61274 | — | — | 1 | 7.14 |
| CHEMBL433041 | EPTASTIGMINE | 2.0 | 1 | 6.96 |
| CHEMBL413549 | — | — | 1 | 6.90 |
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 6.89 |
| CHEMBL64633 | — | — | 1 | 6.88 |
| CHEMBL64529 | — | — | 1 | 6.84 |
| CHEMBL302168 | — | — | 1 | 6.80 |
| CHEMBL60379 | — | — | 1 | 6.77 |
| CHEMBL292421 | — | — | 1 | 6.77 |
| CHEMBL60380 | — | — | 1 | 6.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL413765 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL61274 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL433041 | EPTASTIGMINE | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL413549 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL64633 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL64529 | — | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL302168 | — | IC50 | = | 159.0 | nM | 6.80 |
| CHEMBL60379 | — | IC50 | = | 171.0 | nM | 6.77 |
| CHEMBL292421 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL60380 | — | IC50 | = | 206.0 | nM | 6.69 |