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Assay Detail

CHEMBL645004

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro inhibitory activity against human recombinant AChE
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Acetylcholinesterase (CHEMBL220)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Oxyaniliniums as acetylcholinesterase inhibitors for the reversal of neuromuscular block.
Grove SJ, Kaur J, Muir AW, Pow E, Tarver GJ, Zhang MQ.
Bioorg Med Chem Lett (2002) 12 : 193 -196
PubMed 11755352 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 40 5.75 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL54126 NEOSTIGMINE BROMIDE 2.0 1 8.70
CHEMBL60074 1 6.48
CHEMBL59192 1 6.00
CHEMBL58194 1 6.00
CHEMBL59074 1 5.98
CHEMBL300170 1 5.89
CHEMBL60596 1 5.73
CHEMBL59790 1 5.52
CHEMBL61312 1 5.52
CHEMBL60745 EDROPHONIUM BROMIDE 1 5.40
CHEMBL58511 1 5.00
CHEMBL61515 1 5.00
CHEMBL62031 1 5.00
CHEMBL60180 1 5.00
CHEMBL61965 1 5.00
CHEMBL294674 1 -
CHEMBL57842 1 -
CHEMBL299898 1 -
CHEMBL59490 1 -
CHEMBL293316 1 -
CHEMBL61180 1 -
CHEMBL294152 1 -
CHEMBL60874 1 -
CHEMBL305386 1 -
CHEMBL294897 1 -
CHEMBL58190 1 -
CHEMBL294292 1 -
CHEMBL294251 1 -
CHEMBL61126 1 -
CHEMBL58252 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL54126 NEOSTIGMINE BROMIDE IC50 = 2.0 nM 8.70
CHEMBL60074 IC50 = 330.0 nM 6.48
CHEMBL59192 IC50 = 1000.0 nM 6.00
CHEMBL58194 IC50 = 1000.0 nM 6.00
CHEMBL59074 IC50 = 1040.0 nM 5.98
CHEMBL300170 IC50 = 1300.0 nM 5.89
CHEMBL60596 IC50 = 1850.0 nM 5.73
CHEMBL59790 IC50 = 3000.0 nM 5.52
CHEMBL61312 IC50 = 3000.0 nM 5.52
CHEMBL60745 EDROPHONIUM BROMIDE IC50 = 3960.0 nM 5.40
CHEMBL62031 IC50 = 10000.0 nM 5.00
CHEMBL61515 IC50 = 10000.0 nM 5.00
CHEMBL60180 IC50 = 10000.0 nM 5.00
CHEMBL58511 IC50 = 10000.0 nM 5.00
CHEMBL61965 IC50 = 10000.0 nM 5.00
CHEMBL442361 IC50 > 10000.0 nM -
CHEMBL58034 IC50 > 10000.0 nM -
CHEMBL62210 IC50 > 10000.0 nM -
CHEMBL57003 IC50 > 10000.0 nM -
CHEMBL291783 IC50 > 10000.0 nM -
CHEMBL294498 IC50 > 10000.0 nM -
CHEMBL293268 IC50 > 10000.0 nM -
CHEMBL293751 IC50 > 10000.0 nM -
CHEMBL300176 IC50 > 10000.0 nM -
CHEMBL61905 IC50 > 10000.0 nM -
CHEMBL294674 IC50 > 10000.0 nM -
CHEMBL57842 IC50 > 10000.0 nM -
CHEMBL299898 IC50 > 10000.0 nM -
CHEMBL59490 IC50 > 10000.0 nM -
CHEMBL293316 IC50 > 10000.0 nM -
CHEMBL61180 IC50 > 10000.0 nM -
CHEMBL294152 IC50 > 10000.0 nM -
CHEMBL60874 IC50 > 10000.0 nM -
CHEMBL305386 IC50 > 10000.0 nM -
CHEMBL294897 IC50 > 10000.0 nM -
CHEMBL58190 IC50 > 10000.0 nM -
CHEMBL294292 IC50 > 10000.0 nM -
CHEMBL294251 IC50 > 10000.0 nM -
CHEMBL61126 IC50 > 10000.0 nM -
CHEMBL58252 IC50 > 10000.0 nM -