Assay Detail
Binding
CHEMBL645015
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Binding affinity against Adenosine A1 receptor in rat cortex by displacement of [3H]cyclohexyladenosine (CHA)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
1,3,8-trisubstituted xanthines. Effects of substitution pattern upon adenosine receptor A1/A2 affinity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.89 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL33722 | — | — | 1 | 8.49 |
| CHEMBL286347 | — | — | 1 | 8.33 |
| CHEMBL33169 | — | — | 1 | 8.19 |
| CHEMBL33893 | — | — | 1 | 8.01 |
| CHEMBL287010 | — | — | 1 | 7.94 |
| CHEMBL285212 | — | — | 1 | 7.15 |
| CHEMBL284598 | — | — | 1 | 7.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL33722 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL286347 | — | Ki | = | 4.68 | nM | 8.33 |
| CHEMBL33169 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL33893 | — | Ki | = | 9.68 | nM | 8.01 |
| CHEMBL287010 | — | Ki | = | 11.6 | nM | 7.94 |
| CHEMBL285212 | — | Ki | = | 70.2 | nM | 7.15 |
| CHEMBL284598 | — | Ki | = | 72.8 | nM | 7.14 |