Assay Detail

CHEMBL645105

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Binding affinity for human Alpha-2B adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosin

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

Alpha-2B adrenergic receptor (CHEMBL1942) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

Alpha-2B adrenergic receptor (CHEMBL1942) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Alpha-2B adrenergic receptor

CHEMBL1942

Anchored from Assay target.

Protein identity Alpha-2B adrenergic receptor

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Expert

Target

Alpha-2B adrenergic receptor (CHEMBL1942) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Pharmacological evaluation of UK-14,304 analogs at cloned human adrenergic receptors

Jeon YT, Luo C, Forray C, Vaysse PJ, Branchek TA, Gluchowski C
Bioorg Med Chem Lett (1995) 5 : 2255 -2258
· DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	8.05	8.05

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL49137	—	—	1	8.05

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL49137	—	Ki	=	8.913	nM	8.05