Assay Detail
Binding
CHEMBL645106
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Binding affinity for human Alpha-2B adrenergic receptor from cultured Y-1 cells using [3H]rauwolscine
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Y-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Pharmacological evaluation of UK-14,304 analogs at cloned human adrenergic receptors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.02 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL844 | BRIMONIDINE | 4.0 | 1 | 7.46 |
| CHEMBL74283 | — | — | 1 | 7.31 |
| CHEMBL72753 | — | — | 1 | 7.16 |
| CHEMBL49395 | — | — | 1 | 6.66 |
| CHEMBL72147 | — | — | 1 | 6.49 |
| CHEMBL72995 | — | — | 1 | 5.49 |
| CHEMBL73392 | — | — | 1 | 4.76 |
| CHEMBL74342 | — | — | 1 | 4.74 |
| CHEMBL73164 | — | — | 1 | 4.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL844 | BRIMONIDINE | Ki | = | 34.67 | nM | 7.46 |
| CHEMBL74283 | — | Ki | = | 48.98 | nM | 7.31 |
| CHEMBL72753 | — | Ki | = | 69.18 | nM | 7.16 |
| CHEMBL49395 | — | Ki | = | 218.78 | nM | 6.66 |
| CHEMBL72147 | — | Ki | = | 323.59 | nM | 6.49 |
| CHEMBL72995 | — | Ki | = | 3235.94 | nM | 5.49 |
| CHEMBL73392 | — | Ki | = | 17378.01 | nM | 4.76 |
| CHEMBL74342 | — | Ki | = | 18197.01 | nM | 4.74 |
| CHEMBL73164 | — | Ki | = | 85113.8 | nM | 4.07 |