Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL645172

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Adenylate cyclase activity measured as 50% inhibitory concentration
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Adenylate cyclase (CHEMBL2095179)
Type PROTEIN FAMILY
Organism Rattus norvegicus

Publication

A new approach to search for the bioactive conformation of glucagon: positional cyclization scanning.
Ahn JM, Gitu PM, Medeiros M, Swift JR, Trivedi D, Hruby VJ.
J Med Chem (2001) 44 : 3109 -3116
PubMed 11543679 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 14 6.93 9.57

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL412488 1 9.57
CHEMBL5314341 GLUCAGON 4.0 1 8.23
CHEMBL439885 1 8.20
CHEMBL269490 1 7.64
CHEMBL263603 1 7.38
CHEMBL442135 1 7.33
CHEMBL414077 1 7.23
CHEMBL409654 1 6.63
CHEMBL267189 1 6.53
CHEMBL414490 1 6.53
CHEMBL428460 1 6.41
CHEMBL437465 1 5.23
CHEMBL410553 1 5.12
CHEMBL441011 1 5.04

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL412488 EC50 = 0.27 nM 9.57
CHEMBL5314341 GLUCAGON EC50 = 5.9 nM 8.23
CHEMBL439885 EC50 = 6.3 nM 8.20
CHEMBL269490 EC50 = 23.0 nM 7.64
CHEMBL263603 EC50 = 41.8 nM 7.38
CHEMBL442135 EC50 = 47.0 nM 7.33
CHEMBL414077 EC50 = 59.0 nM 7.23
CHEMBL409654 EC50 = 236.0 nM 6.63
CHEMBL267189 EC50 = 295.0 nM 6.53
CHEMBL414490 EC50 = 295.0 nM 6.53
CHEMBL428460 EC50 = 390.0 nM 6.41
CHEMBL437465 EC50 = 5900.0 nM 5.23
CHEMBL410553 EC50 = 7500.0 nM 5.12
CHEMBL441011 EC50 = 9200.0 nM 5.04