Assay Detail
Binding
CHEMBL645175
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for ability to stimulate dopamine sensitive adenylate cyclase in rat caudate homogenate
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Absolute stereochemistry and dopaminergic activity of enantiomers of 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.70 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1467585 | — | — | 1 | 7.50 |
| CHEMBL542700 | — | — | 1 | 7.15 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1467585 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL542700 | — | EC50 | = | 71.0 | nM | 7.15 |
| CHEMBL59 | DOPAMINE | EC50 | = | 3500.0 | nM | 5.46 |