Assay Detail
Binding
CHEMBL645210
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Affinity for Alpha-2 adrenergic receptor of rat cortical membranes
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Discovery of a series of (4,5-dihydroimidazol-2-yl)-biphenylamine 5-HT7 agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 7.65 | 8.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL327654 | — | — | 1 | 8.29 |
| CHEMBL329548 | — | — | 1 | 8.21 |
| CHEMBL94017 | — | — | 1 | 8.00 |
| CHEMBL90118 | — | — | 1 | 7.96 |
| CHEMBL90752 | — | — | 1 | 7.75 |
| CHEMBL92221 | — | — | 1 | 7.71 |
| CHEMBL544315 | — | — | 1 | 7.66 |
| CHEMBL327906 | — | — | 1 | 7.62 |
| CHEMBL316283 | — | — | 1 | 7.59 |
| CHEMBL90538 | — | — | 1 | 7.58 |
| CHEMBL540821 | — | — | 1 | 7.49 |
| CHEMBL92856 | — | — | 1 | 7.13 |
| CHEMBL90150 | — | — | 1 | 7.10 |
| CHEMBL94056 | — | — | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL327654 | — | Ki | = | 5.129 | nM | 8.29 |
| CHEMBL329548 | — | Ki | = | 6.166 | nM | 8.21 |
| CHEMBL94017 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL90118 | — | Ki | = | 10.96 | nM | 7.96 |
| CHEMBL90752 | — | Ki | = | 17.78 | nM | 7.75 |
| CHEMBL92221 | — | Ki | = | 19.5 | nM | 7.71 |
| CHEMBL544315 | — | Ki | = | 21.88 | nM | 7.66 |
| CHEMBL327906 | — | Ki | = | 23.99 | nM | 7.62 |
| CHEMBL316283 | — | Ki | = | 25.7 | nM | 7.59 |
| CHEMBL90538 | — | Ki | = | 26.3 | nM | 7.58 |
| CHEMBL540821 | — | Ki | = | 32.36 | nM | 7.49 |
| CHEMBL92856 | — | Ki | = | 74.13 | nM | 7.13 |
| CHEMBL90150 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL94056 | — | Ki | = | 109.65 | nM | 6.96 |