Assay Detail
Binding
CHEMBL645211
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Displacement of [3H]clonidine from rat cortex membrane Alpha-2 adrenergic receptors
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Imidazoline binding sites (IBS) profile modulation: key role of the bridge in determining I1-IBS or I2-IBS selectivity within a series of 2-phenoxymethylimidazoline analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 6.04 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14640 | — | — | 1 | 7.28 |
| CHEMBL273485 | — | — | 1 | 7.01 |
| CHEMBL93845 | — | — | 1 | 6.92 |
| CHEMBL94022 | — | — | 1 | 6.62 |
| CHEMBL67706 | — | — | 1 | 6.40 |
| CHEMBL68608 | — | — | 1 | 5.93 |
| CHEMBL1907831 | — | — | 1 | 5.90 |
| CHEMBL2092860 | — | — | 1 | 5.80 |
| CHEMBL14210 | PHENYZOLINE | — | 1 | 5.70 |
| CHEMBL71429 | — | — | 1 | 5.45 |
| CHEMBL1907832 | — | — | 1 | 5.40 |
| CHEMBL2092861 | — | — | 1 | 5.30 |
| CHEMBL275970 | TRACIZOLINE | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14640 | — | Ki | = | 52.48 | nM | 7.28 |
| CHEMBL273485 | — | Ki | = | 97.72 | nM | 7.01 |
| CHEMBL93845 | — | Ki | = | 120.23 | nM | 6.92 |
| CHEMBL94022 | — | Ki | = | 239.88 | nM | 6.62 |
| CHEMBL67706 | — | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL68608 | — | Ki | = | 1174.9 | nM | 5.93 |
| CHEMBL1907831 | — | Ki | = | 1258.93 | nM | 5.90 |
| CHEMBL2092860 | — | Ki | = | 1584.89 | nM | 5.80 |
| CHEMBL14210 | PHENYZOLINE | Ki | = | 1995.26 | nM | 5.70 |
| CHEMBL71429 | — | Ki | = | 3548.13 | nM | 5.45 |
| CHEMBL1907832 | — | Ki | = | 3981.07 | nM | 5.40 |
| CHEMBL2092861 | — | Ki | = | 5011.87 | nM | 5.30 |
| CHEMBL275970 | TRACIZOLINE | Ki | = | 14125.38 | nM | 4.85 |