Assay Detail
Binding
CHEMBL645245
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In vitro inhibition of [3H]prazosin binding to rat alpha-1 adrenergic receptors.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
1-aryl-4-[(5-methoxy-1,2,3, 4-tetrahydronaphthalen-1-yl)alkyl]piperazines and their analogues: influence of the stereochemistry of the tetrahydronaphthalen-1-yl nucleus on 5-HT1A receptor affinity and selectivity versus alpha1 and D2 receptors. 5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.82 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL144523 | — | — | 1 | 9.10 |
| CHEMBL26929 | — | — | 1 | 8.19 |
| CHEMBL147659 | — | — | 1 | 7.48 |
| CHEMBL322275 | — | — | 1 | 7.37 |
| CHEMBL147963 | — | — | 1 | 7.21 |
| CHEMBL444590 | — | — | 1 | 7.18 |
| CHEMBL148186 | — | — | 1 | 7.07 |
| CHEMBL28063 | — | — | 1 | 6.82 |
| CHEMBL108241 | — | — | 1 | 6.66 |
| CHEMBL148234 | — | — | 1 | 6.64 |
| CHEMBL435029 | — | — | 1 | 6.62 |
| CHEMBL148288 | — | — | 1 | 6.24 |
| CHEMBL147692 | — | — | 1 | 6.19 |
| CHEMBL359245 | — | — | 1 | 6.11 |
| CHEMBL107486 | — | — | 1 | 6.05 |
| CHEMBL147861 | — | — | 1 | 6.02 |
| CHEMBL147371 | — | — | 1 | 6.00 |
| CHEMBL148397 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL144523 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL26929 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL147659 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL322275 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL147963 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL444590 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL148186 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL28063 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL108241 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL148234 | — | IC50 | = | 228.0 | nM | 6.64 |
| CHEMBL435029 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL148288 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL147692 | — | IC50 | = | 649.0 | nM | 6.19 |
| CHEMBL359245 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL107486 | — | IC50 | = | 881.0 | nM | 6.05 |
| CHEMBL147861 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL147371 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL148397 | — | IC50 | = | 1700.0 | nM | 5.77 |