Assay Detail
Binding
CHEMBL645247
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]prazosin at alpha-1 adrenergic receptor in rat brain cortices (n=1)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Subtype-selective N-methyl-D-aspartate receptor antagonists: synthesis and biological evaluation of 1-(heteroarylalkynyl)-4-benzylpiperidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.45 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL117260 | — | — | 1 | 6.30 |
| CHEMBL19636 | — | — | 1 | 6.16 |
| CHEMBL19506 | — | — | 1 | 5.92 |
| CHEMBL419399 | — | — | 1 | 5.51 |
| CHEMBL325825 | — | — | 1 | 5.24 |
| CHEMBL326568 | — | — | 1 | 4.77 |
| CHEMBL326742 | — | — | 1 | 4.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL117260 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL19636 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL19506 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL419399 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL325825 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL326568 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL326742 | — | IC50 | = | 55000.0 | nM | 4.26 |