Assay Detail
Binding
CHEMBL645249
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In vitro binding affinity measured on alpha-1 adrenergic receptor using [3H]prazosin as radioligand.
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
High affinity and selectivity on 5-HT1A receptor of 1-aryl-4-[1-tetralin)alkyl]piperazines. 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.18 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL368477 | — | — | 1 | 9.85 |
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 9.36 |
| CHEMBL174083 | — | — | 1 | 8.90 |
| CHEMBL26929 | — | — | 1 | 8.71 |
| CHEMBL174300 | — | — | 1 | 8.44 |
| CHEMBL173190 | — | — | 1 | 8.22 |
| CHEMBL366459 | — | — | 1 | 7.82 |
| CHEMBL367435 | — | — | 1 | 7.61 |
| CHEMBL444590 | — | — | 1 | 7.50 |
| CHEMBL172161 | — | — | 1 | 7.49 |
| CHEMBL424125 | — | — | 1 | 7.37 |
| CHEMBL148055 | — | — | 1 | 7.31 |
| CHEMBL140406 | — | — | 1 | 7.14 |
| CHEMBL28209 | — | — | 1 | 7.11 |
| CHEMBL172363 | — | — | 1 | 7.11 |
| CHEMBL322275 | — | — | 1 | 7.10 |
| CHEMBL174554 | — | — | 1 | 7.02 |
| CHEMBL172556 | — | — | 1 | 6.94 |
| CHEMBL174703 | — | — | 1 | 6.92 |
| CHEMBL175300 | — | — | 1 | 6.91 |
| CHEMBL108241 | — | — | 1 | 6.83 |
| CHEMBL277302 | — | — | 1 | 6.82 |
| CHEMBL143110 | — | — | 1 | 6.80 |
| CHEMBL172601 | — | — | 1 | 6.74 |
| CHEMBL171181 | — | — | 1 | 6.58 |
| CHEMBL171974 | — | — | 1 | 6.56 |
| CHEMBL425134 | — | — | 1 | 5.71 |
| CHEMBL367723 | — | — | 1 | 5.53 |
| CHEMBL433972 | — | — | 1 | 5.51 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL368477 | — | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL2 | PRAZOSIN | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL174083 | — | IC50 | = | 1.26 | nM | 8.90 |
| CHEMBL26929 | — | IC50 | = | 1.94 | nM | 8.71 |
| CHEMBL174300 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL173190 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL366459 | — | IC50 | = | 15.3 | nM | 7.82 |
| CHEMBL367435 | — | IC50 | = | 24.5 | nM | 7.61 |
| CHEMBL444590 | — | IC50 | = | 31.4 | nM | 7.50 |
| CHEMBL172161 | — | IC50 | = | 32.3 | nM | 7.49 |
| CHEMBL424125 | — | IC50 | = | 43.2 | nM | 7.37 |
| CHEMBL148055 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL140406 | — | IC50 | = | 72.2 | nM | 7.14 |
| CHEMBL28209 | — | IC50 | = | 78.3 | nM | 7.11 |
| CHEMBL172363 | — | IC50 | = | 78.5 | nM | 7.11 |
| CHEMBL322275 | — | IC50 | = | 78.8 | nM | 7.10 |
| CHEMBL174554 | — | IC50 | = | 96.2 | nM | 7.02 |
| CHEMBL172556 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL174703 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL175300 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL108241 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL277302 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL143110 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL172601 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL171181 | — | IC50 | = | 261.0 | nM | 6.58 |
| CHEMBL171974 | — | IC50 | = | 278.0 | nM | 6.56 |
| CHEMBL425134 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL367723 | — | IC50 | = | 2930.0 | nM | 5.53 |
| CHEMBL433972 | — | IC50 | = | 3070.0 | nM | 5.51 |
| CHEMBL49 | BUSPIRONE | IC50 | = | 4160.0 | nM | 5.38 |
| CHEMBL176819 | — | IC50 | = | 7170.0 | nM | 5.14 |