Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL645253

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Potency to antagonize the ability of angiotensin II to contract rabbit aorta
ChEMBL ↗
100
Total Activities
100
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Oryctolagus cuniculus
Tissue Aorta
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Angiotensin II receptor (CHEMBL2094256) ↗
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

2-(Alkylamino)nicotinic acid and analogs. Potent angiotensin II antagonists.
Winn M, De B, Zydowsky TM, Altenbach RJ, Basha FZ, Boyd SA, Brune ME, Buckner SA, Crowell D, Drizin I.
J Med Chem (1993) 36 : 2676 -2688
PubMed 8410980 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 100 8.17 10.33

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL125218 — — 1 10.33
CHEMBL92542 — — 1 10.25
CHEMBL416477 — — 1 10.10
CHEMBL907 CARBOXYLIC ACID METABOLITE — 1 9.71
CHEMBL88411 — — 1 9.70
CHEMBL315728 — — 1 9.69
CHEMBL49410 — — 1 9.68
CHEMBL91255 — — 1 9.64
CHEMBL7550 L-158809 — 1 9.63
CHEMBL92062 — — 1 9.63
CHEMBL421473 — — 1 9.60
CHEMBL1237157 — — 1 9.57
CHEMBL327342 — — 1 9.27
CHEMBL327932 — — 1 9.12
CHEMBL327784 — — 1 9.07
CHEMBL327488 — — 1 9.07
CHEMBL89404 — — 1 9.04
CHEMBL315149 — — 1 9.04
CHEMBL329611 — — 1 9.00
CHEMBL92256 — — 1 8.96
CHEMBL432827 — — 1 8.91
CHEMBL91144 — — 1 8.90
CHEMBL1202855 — — 1 8.85
CHEMBL91018 — — 1 8.84
CHEMBL1237156 — — 1 8.81
CHEMBL443269 — — 1 8.80
CHEMBL89484 — — 1 8.80
CHEMBL315148 — — 1 8.79
CHEMBL440521 — — 1 8.77
CHEMBL327645 — — 1 8.73

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL125218 — Kd = 0.04677 nM 10.33
CHEMBL92542 — Kd = 0.05623 nM 10.25
CHEMBL416477 — Kd = 0.07943 nM 10.10
CHEMBL907 CARBOXYLIC ACID METABOLITE Kd = 0.195 nM 9.71
CHEMBL88411 — Kd = 0.1995 nM 9.70
CHEMBL315728 — Kd = 0.2042 nM 9.69
CHEMBL49410 — Kd = 0.2089 nM 9.68
CHEMBL91255 — Kd = 0.2291 nM 9.64
CHEMBL7550 L-158809 Kd = 0.2344 nM 9.63
CHEMBL92062 — Kd = 0.2344 nM 9.63
CHEMBL421473 — Kd = 0.2512 nM 9.60
CHEMBL1237157 — Kd = 0.2692 nM 9.57
CHEMBL327342 — Kd = 0.537 nM 9.27
CHEMBL327932 — Kd = 0.7586 nM 9.12
CHEMBL327488 — Kd = 0.8511 nM 9.07
CHEMBL327784 — Kd = 0.8511 nM 9.07
CHEMBL89404 — Kd = 0.912 nM 9.04
CHEMBL315149 — Kd = 0.912 nM 9.04
CHEMBL329611 — Kd = 1.0 nM 9.00
CHEMBL92256 — Kd = 1.096 nM 8.96
CHEMBL432827 — Kd = 1.23 nM 8.91
CHEMBL91144 — Kd = 1.259 nM 8.90
CHEMBL1202855 — Kd = 1.413 nM 8.85
CHEMBL91018 — Kd = 1.445 nM 8.84
CHEMBL1237156 — Kd = 1.549 nM 8.81
CHEMBL443269 — Kd = 1.585 nM 8.80
CHEMBL89484 — Kd = 1.585 nM 8.80
CHEMBL315148 — Kd = 1.622 nM 8.79
CHEMBL440521 — Kd = 1.698 nM 8.77
CHEMBL327645 — Kd = 1.862 nM 8.73
CHEMBL89164 — Kd = 2.239 nM 8.65
CHEMBL88806 — Kd = 2.63 nM 8.58
CHEMBL327670 — Kd = 2.754 nM 8.56
CHEMBL316062 — Kd = 3.02 nM 8.52
CHEMBL92258 — Kd = 3.162 nM 8.50
CHEMBL88231 — Kd = 3.311 nM 8.48
CHEMBL329212 — Kd = 3.311 nM 8.48
CHEMBL329149 — Kd = 3.548 nM 8.45
CHEMBL314319 — Kd = 3.631 nM 8.44
CHEMBL191 LOSARTAN Kd = 3.715 nM 8.43
CHEMBL90886 — Kd = 4.169 nM 8.38
CHEMBL314999 — Kd = 4.169 nM 8.38
CHEMBL92319 — Kd = 4.677 nM 8.33
CHEMBL1202854 — Kd = 4.786 nM 8.32
CHEMBL92166 — Kd = 4.898 nM 8.31
CHEMBL1202852 — Kd = 5.012 nM 8.30
CHEMBL1202857 — Kd = 5.37 nM 8.27
CHEMBL121635 — Kd = 7.079 nM 8.15
CHEMBL88371 — Kd = 7.586 nM 8.12
CHEMBL91681 — Kd = 8.318 nM 8.08