Assay Detail
Binding
CHEMBL645284
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated In vitro for inhibition of aldose reductase activity by 50% in dog RBC
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL1900) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel spirosuccinimide aldose reductase inhibitors derived from isoquinoline-1,3-diones: 2-[(4-bromo-2-fluorophenyl)methyl]-6- fluorospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrone and congeners. 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.75 | 7.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL273910 | MINALRESTAT | 2.0 | 1 | 7.91 |
| CHEMBL62685 | — | — | 1 | 7.71 |
| CHEMBL436 | TOLRESTAT | 4.0 | 1 | 7.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL273910 | MINALRESTAT | IC50 | = | 12.2 | nM | 7.91 |
| CHEMBL62685 | — | IC50 | = | 19.4 | nM | 7.71 |
| CHEMBL436 | TOLRESTAT | IC50 | = | 23.9 | nM | 7.62 |