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Assay Detail

CHEMBL645285

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Binding
Inhibition of Angiotensin I converting enzyme
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Angiotensin-converting enzyme (CHEMBL1808)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Conformational analysis and active site modelling of angiotensin-converting enzyme inhibitors.
Andrews PR, Carson JM, Caselli A, Spark MJ, Woods R.
J Med Chem (1985) 28 : 393 -399
PubMed 2983076 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 7.94 9.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL340528 1 9.22
CHEMBL2304318 1 8.92
CHEMBL290284 1 8.52
CHEMBL131552 1 8.49
CHEMBL611148 1 8.43
CHEMBL311525 1 8.05
CHEMBL1560 CAPTOPRIL 4.0 1 7.70
CHEMBL110444 1 7.19
CHEMBL305938 1 6.70
CHEMBL128223 DEHYDROCAPTOPRIL 1 6.19
CHEMBL10962 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL340528 IC50 = 0.6 nM 9.22
CHEMBL2304318 IC50 = 1.2 nM 8.92
CHEMBL290284 IC50 = 3.0 nM 8.52
CHEMBL131552 IC50 = 3.2 nM 8.49
CHEMBL611148 IC50 = 3.7 nM 8.43
CHEMBL311525 IC50 = 9.0 nM 8.05
CHEMBL1560 CAPTOPRIL IC50 = 20.0 nM 7.70
CHEMBL110444 IC50 = 65.0 nM 7.19
CHEMBL305938 IC50 = 200.0 nM 6.70
CHEMBL128223 DEHYDROCAPTOPRIL IC50 = 650.0 nM 6.19
CHEMBL10962 IC50 = 1800000.0 nM -