Assay Detail
Binding
CHEMBL645286
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Inhibition of Angiotensin I converting enzyme
13
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Dual metalloprotease inhibitors. II. Effect of substitution and stereochemistry on benzazepinone based mercaptoacetyls
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.48 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL299875 | — | — | 1 | 8.27 |
| CHEMBL415932 | — | — | 1 | 8.20 |
| CHEMBL299639 | — | — | 1 | 7.92 |
| CHEMBL300016 | — | — | 1 | 7.85 |
| CHEMBL299169 | — | — | 1 | 7.66 |
| CHEMBL299438 | — | — | 1 | 7.66 |
| CHEMBL50480 | — | — | 1 | 7.62 |
| CHEMBL50814 | — | — | 1 | 7.60 |
| CHEMBL51576 | — | — | 1 | 7.48 |
| CHEMBL48534 | — | — | 2 | 7.20 |
| CHEMBL422944 | — | — | 1 | 6.55 |
| CHEMBL50315 | — | — | 1 | 6.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL299875 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL415932 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL299639 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL300016 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL299169 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL299438 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL50480 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL50814 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL51576 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL48534 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL48534 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL422944 | — | IC50 | = | 284.0 | nM | 6.55 |
| CHEMBL50315 | — | IC50 | = | 306.0 | nM | 6.51 |