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Assay Detail

CHEMBL645287

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Binding
In vitro inhibitory activity against Angiotensin I converting enzyme
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Angiotensin-converting enzyme (CHEMBL1808)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Angiotensin-converting enzyme inhibitors: synthesis and biological activity of acyl tripeptide analogues of enalapril.
Greenlee WJ, Allibone PL, Perlow DS, Patchett AA, Ulm EH, Vassil TC.
J Med Chem (1985) 28 : 434 -442
PubMed 2984419 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 7.63 8.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL577 ENALAPRILAT ANHYDROUS 4.0 1 8.92
CHEMBL263460 1 8.54
CHEMBL335997 1 8.54
CHEMBL2112768 1 8.52
CHEMBL2111940 1 8.32
CHEMBL136312 1 8.27
CHEMBL342373 1 8.22
CHEMBL2112769 1 8.11
CHEMBL434617 1 8.07
CHEMBL342652 1 8.03
CHEMBL435360 1 7.92
CHEMBL2112767 1 7.77
CHEMBL1560 CAPTOPRIL 4.0 1 7.70
CHEMBL2111941 1 7.40
CHEMBL2370850 1 7.30
CHEMBL3037879 1 6.16
CHEMBL2111942 1 5.85
CHEMBL28361 1 5.85
CHEMBL2370854 1 5.57
CHEMBL2370859 1 -
CHEMBL139523 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL577 ENALAPRILAT ANHYDROUS IC50 = 1.2 nM 8.92
CHEMBL263460 IC50 = 2.9 nM 8.54
CHEMBL335997 IC50 = 2.9 nM 8.54
CHEMBL2112768 IC50 = 3.0 nM 8.52
CHEMBL2111940 IC50 = 4.8 nM 8.32
CHEMBL136312 IC50 = 5.4 nM 8.27
CHEMBL342373 IC50 = 6.0 nM 8.22
CHEMBL2112769 IC50 = 7.7 nM 8.11
CHEMBL434617 IC50 = 8.5 nM 8.07
CHEMBL342652 IC50 = 9.4 nM 8.03
CHEMBL435360 IC50 = 12.0 nM 7.92
CHEMBL2112767 IC50 = 17.0 nM 7.77
CHEMBL1560 CAPTOPRIL IC50 = 20.0 nM 7.70
CHEMBL2111941 IC50 = 40.0 nM 7.40
CHEMBL2370850 IC50 = 50.0 nM 7.30
CHEMBL3037879 IC50 = 700.0 nM 6.16
CHEMBL2111942 IC50 = 1400.0 nM 5.85
CHEMBL28361 IC50 = 1400.0 nM 5.85
CHEMBL2370854 IC50 = 2700.0 nM 5.57
CHEMBL2370859 IC50 = 330000.0 nM -
CHEMBL139523 IC50 = 2600000.0 nM -