Assay Detail
Binding
CHEMBL645288
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Compound tested in vitro for inhibition of Angiotensin I converting enzyme
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Angiotensin converting enzyme inhibitors: spirapril and related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.91 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL295690 | — | — | 1 | 9.30 |
| CHEMBL579 | SPIRAPRILAT | 2.0 | 1 | 9.10 |
| CHEMBL577 | ENALAPRILAT ANHYDROUS | 4.0 | 1 | 8.59 |
| CHEMBL1560 | CAPTOPRIL | 4.0 | 1 | 7.89 |
| CHEMBL415881 | — | — | 1 | 6.70 |
| CHEMBL578 | ENALAPRIL | 4.0 | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL295690 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL579 | SPIRAPRILAT | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL577 | ENALAPRILAT ANHYDROUS | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 12.9 | nM | 7.89 |
| CHEMBL415881 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL578 | ENALAPRIL | IC50 | = | 1273.0 | nM | 5.89 |