Assay Detail
Binding
CHEMBL645292
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In vitro inhibition of dopamine stimulated adenylate cyclase
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Carassius auratus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological evaluation of 1-(aminomethyl)-3,4-dihydro-5-hydroxy-1H-2-benzopyrans as dopamine D1 selective ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.13 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | — | 1 | 8.89 |
| CHEMBL543390 | — | — | 1 | 7.49 |
| CHEMBL541838 | — | — | 1 | 7.28 |
| CHEMBL542436 | — | — | 1 | 7.00 |
| CHEMBL544099 | — | — | 1 | 6.92 |
| CHEMBL545264 | — | — | 1 | 6.90 |
| CHEMBL538520 | — | — | 1 | 6.71 |
| CHEMBL555619 | — | — | 1 | 6.61 |
| CHEMBL543389 | — | — | 1 | 6.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL543390 | — | Ki | = | 32.4 | nM | 7.49 |
| CHEMBL541838 | — | Ki | = | 52.5 | nM | 7.28 |
| CHEMBL542436 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL544099 | — | Ki | = | 121.0 | nM | 6.92 |
| CHEMBL545264 | — | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL538520 | — | Ki | = | 197.0 | nM | 6.71 |
| CHEMBL555619 | — | Ki | = | 247.0 | nM | 6.61 |
| CHEMBL543389 | — | Ki | = | 454.0 | nM | 6.34 |