Assay Detail
Binding
CHEMBL645374
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for inhibition of adenylate cyclase from rat brain
10
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of 2',5'-dideoxy-2-fluoroadenosine and 2',5'-dideoxy-2,5'-difluoroadenosine: potent P-site inhibitors of adenylyl cyclase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.20 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2079578 | — | — | 2 | 6.05 |
| CHEMBL2079579 | — | — | 2 | 6.01 |
| CHEMBL2448167 | — | — | 1 | 5.55 |
| CHEMBL1229920 | — | — | 2 | 5.34 |
| CHEMBL449329 | DEOXYADENOSINE | — | 1 | 4.82 |
| CHEMBL1090 | VIDARABINE | 4.0 | 1 | 4.09 |
| CHEMBL477 | ADENOSINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2079578 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL2079579 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL2448167 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL1229920 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL449329 | DEOXYADENOSINE | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL2079579 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL1090 | VIDARABINE | IC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL2079578 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL477 | ADENOSINE | IC50 | > | 300000.0 | nM | - |
| CHEMBL1229920 | — | IC50 | > | 100000.0 | nM | - |