Assay Detail
Functional
CHEMBL645375
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Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Combined analgesic/neuroleptic activity in N-butyrophenone prodine-like compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.65 | 6.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 6.26 |
| CHEMBL1160253 | — | — | 1 | 5.82 |
| CHEMBL57029 | — | — | 1 | 5.78 |
| CHEMBL299471 | — | — | 1 | 5.62 |
| CHEMBL57140 | — | — | 1 | 5.58 |
| CHEMBL292006 | — | — | 1 | 5.58 |
| CHEMBL54206 | — | — | 1 | 5.55 |
| CHEMBL56547 | — | — | 1 | 5.50 |
| CHEMBL56843 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL1160253 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL57029 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL299471 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL57140 | — | IC50 | = | 2650.0 | nM | 5.58 |
| CHEMBL292006 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL54206 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL56547 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL56843 | — | IC50 | = | 7500.0 | nM | 5.12 |