Assay Detail
Binding
CHEMBL645395
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Affinity for alpha-1 adrenergic receptor
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Azepinoindole derivatives with high affinity for brain dopamine and serotonin receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.53 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 8.52 |
| CHEMBL176990 | — | — | 1 | 7.85 |
| CHEMBL178797 | — | — | 1 | 7.68 |
| CHEMBL176356 | — | — | 1 | 7.66 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.64 |
| CHEMBL171903 | — | — | 1 | 7.46 |
| CHEMBL174949 | — | — | 1 | 7.24 |
| CHEMBL367981 | — | — | 1 | 6.18 |
| CHEMBL176363 | — | — | 1 | - |
| CHEMBL366377 | — | — | 1 | - |
| CHEMBL160430 | — | — | 1 | - |
| CHEMBL366504 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL85 | RISPERIDONE | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL176990 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL178797 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL176356 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL171903 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL174949 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL367981 | — | Ki | = | 660.0 | nM | 6.18 |
| CHEMBL176363 | — | Ki | > | 500.0 | nM | - |
| CHEMBL366377 | — | Ki | < | 1000.0 | nM | - |
| CHEMBL160430 | — | Ki | < | 1000.0 | nM | - |
| CHEMBL366504 | — | Ki | > | 100.0 | nM | - |