Assay Detail
Binding
CHEMBL645452
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Binding affinity for adenosine A2 receptor using [3H]NECA in rat striatal membrane
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
1H-imidazo[4,5-c]quinolin-4-amines: novel non-xanthine adenosine antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.02 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19305 | — | — | 1 | 6.54 |
| CHEMBL276138 | — | — | 1 | 6.54 |
| CHEMBL19095 | — | — | 1 | 6.35 |
| CHEMBL19768 | — | — | 1 | 6.35 |
| CHEMBL19970 | — | — | 1 | 6.13 |
| CHEMBL1907708 | — | — | 1 | 6.09 |
| CHEMBL62350 | 8-PHENYL THEOPHYLLINE | — | 1 | 6.07 |
| CHEMBL1907924 | — | — | 1 | 5.55 |
| CHEMBL1355736 | THEOPHYLLINE | 4.0 | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19305 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL276138 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL19095 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL19768 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL19970 | — | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL1907708 | — | Ki | = | 810.0 | nM | 6.09 |
| CHEMBL62350 | 8-PHENYL THEOPHYLLINE | Ki | = | 850.0 | nM | 6.07 |
| CHEMBL1907924 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL1355736 | THEOPHYLLINE | Ki | = | 25000.0 | nM | 4.60 |