Assay Detail
Functional
CHEMBL645513
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Alpha-2 adrenergic receptor blocking activity by antagonism of clonidine induced depression of twitch response of field stimulated prostatic portion of rat vas deferens
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Vas deferens |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Structure-activity relationships among benextramine-related tetraamine disulfides. Chain length effect on alpha-adrenoreceptor blocking activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.64 | 6.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19060 | BENEXTRAMINE | — | 1 | 6.09 |
| CHEMBL55957 | — | — | 1 | 5.98 |
| CHEMBL299486 | — | — | 1 | 5.91 |
| CHEMBL301293 | — | — | 1 | 4.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19060 | BENEXTRAMINE | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL55957 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL299486 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL301293 | — | IC50 | = | 25800.0 | nM | 4.59 |