Assay Detail
Binding
CHEMBL645515
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Alpha-2-adrenolytic activity was assessed from the ability to inhibit [3H]yohimbine binding to rat cerebral cortex preparation
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
New 1,4-dihydropyridine derivatives combining calcium antagonism and alpha-adrenolytic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.81 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3350238 | — | — | 1 | 6.68 |
| CHEMBL540511 | — | — | 1 | 6.08 |
| CHEMBL1484 | NICARDIPINE | 4.0 | 1 | 5.85 |
| CHEMBL542814 | — | — | 1 | 5.70 |
| CHEMBL2093965 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3350238 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL540511 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL1484 | NICARDIPINE | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL542814 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2093965 | — | IC50 | = | 19000.0 | nM | 4.72 |