Assay Detail
Binding
CHEMBL645519
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Binding affinity towards rat Alpha-2 adrenergic receptor was evaluated using [3H]- yohimbine as radioligand
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Structure-activity relationship studies on the 5-HT(1A) receptor affinity of 1-phenyl-4-[omega-(alpha- or beta-tetralinyl)alkyl]piperazines. 4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.82 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26929 | — | — | 1 | 7.77 |
| CHEMBL144417 | — | — | 1 | 7.66 |
| CHEMBL15245 | YOHIMBINE | 3.0 | 1 | 7.52 |
| CHEMBL444590 | — | — | 1 | 7.32 |
| CHEMBL342518 | — | — | 1 | 6.91 |
| CHEMBL357176 | — | — | 1 | 6.89 |
| CHEMBL145432 | — | — | 1 | 6.85 |
| CHEMBL143728 | — | — | 1 | 6.80 |
| CHEMBL147678 | — | — | 1 | 6.77 |
| CHEMBL322275 | — | — | 1 | 6.58 |
| CHEMBL144445 | — | — | 1 | 6.58 |
| CHEMBL147440 | — | — | 1 | 6.54 |
| CHEMBL147387 | — | — | 1 | 6.45 |
| CHEMBL343432 | — | — | 1 | 6.22 |
| CHEMBL341893 | — | — | 1 | 6.11 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 6.09 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26929 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL144417 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL15245 | YOHIMBINE | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL444590 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL342518 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL357176 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL145432 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL143728 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL147678 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL322275 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL144445 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL147440 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL147387 | — | IC50 | = | 357.0 | nM | 6.45 |
| CHEMBL343432 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL341893 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL56 | 8-OH-DPAT | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL49 | BUSPIRONE | IC50 | > | 10000.0 | nM | - |