Assay Detail
Binding
CHEMBL645520
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Binding affinity against Alpha-2 adrenergic receptor in rat brain membrane using [3H]yohimbine as radioligand
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
1-aryl-4-[(1-tetralinyl)alkyl]piperazines: alkylamido and alkylamino derivatives. Synthesis, 5-HT1A receptor affinity, and selectivity. 3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.36 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26929 | — | — | 1 | 7.77 |
| CHEMBL15245 | YOHIMBINE | 3.0 | 1 | 7.52 |
| CHEMBL444590 | — | — | 1 | 7.32 |
| CHEMBL108245 | — | — | 1 | 7.02 |
| CHEMBL326017 | — | — | 1 | 6.95 |
| CHEMBL108942 | — | — | 1 | 6.84 |
| CHEMBL321184 | — | — | 1 | 6.74 |
| CHEMBL111760 | — | — | 1 | 6.73 |
| CHEMBL325565 | — | — | 1 | 6.60 |
| CHEMBL322275 | — | — | 1 | 6.58 |
| CHEMBL108241 | — | — | 1 | 6.55 |
| CHEMBL325092 | — | — | 1 | 6.51 |
| CHEMBL107486 | — | — | 1 | 6.34 |
| CHEMBL110968 | — | — | 1 | 6.25 |
| CHEMBL324637 | — | — | 1 | 6.13 |
| CHEMBL325079 | — | — | 1 | 6.10 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 6.09 |
| CHEMBL28063 | — | — | 1 | 5.90 |
| CHEMBL323242 | — | — | 1 | 5.88 |
| CHEMBL26426 | — | — | 1 | 5.86 |
| CHEMBL107921 | — | — | 1 | 5.85 |
| CHEMBL320587 | — | — | 1 | 5.73 |
| CHEMBL108858 | — | — | 1 | 5.57 |
| CHEMBL107503 | — | — | 1 | 5.14 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 5.00 |
| CHEMBL109263 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26929 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL15245 | YOHIMBINE | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL444590 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL108245 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL326017 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL108942 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL321184 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL111760 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL325565 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL322275 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL108241 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL325092 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL107486 | — | IC50 | = | 458.0 | nM | 6.34 |
| CHEMBL110968 | — | IC50 | = | 564.0 | nM | 6.25 |
| CHEMBL324637 | — | IC50 | = | 746.0 | nM | 6.13 |
| CHEMBL325079 | — | IC50 | = | 788.0 | nM | 6.10 |
| CHEMBL56 | 8-OH-DPAT | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL28063 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL323242 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL26426 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL107921 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL320587 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL108858 | — | IC50 | = | 2680.0 | nM | 5.57 |
| CHEMBL107503 | — | IC50 | = | 7220.0 | nM | 5.14 |
| CHEMBL49 | BUSPIRONE | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL109263 | — | IC50 | > | 10000.0 | nM | - |