Assay Detail
Binding
CHEMBL645534
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In vitro concentration required for 50% inhibition against Adenosine Kinase (AK) in the presence of enzyme
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Pyridopyrimidine analogues as novel adenosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.59 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL66089 | — | — | 1 | 8.89 |
| CHEMBL62576 | — | — | 1 | 8.89 |
| CHEMBL65665 | — | — | 1 | 8.85 |
| CHEMBL62974 | — | — | 1 | 8.74 |
| CHEMBL302404 | — | — | 1 | 8.47 |
| CHEMBL62524 | — | — | 1 | 8.39 |
| CHEMBL62342 | — | — | 1 | 8.38 |
| CHEMBL65664 | — | — | 1 | 8.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL66089 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL62576 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL65665 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL62974 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL302404 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL62524 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL62342 | — | IC50 | = | 4.12 | nM | 8.38 |
| CHEMBL65664 | — | IC50 | = | 8.0 | nM | 8.10 |