Assay Detail
Binding
CHEMBL645535
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro concentration required for 50% inhibition against Adenosine Kinase (AK) in the presence of intact cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Pyridopyrimidine analogues as novel adenosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.38 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65665 | — | — | 1 | 7.55 |
| CHEMBL62974 | — | — | 1 | 7.48 |
| CHEMBL62342 | — | — | 1 | 7.42 |
| CHEMBL62524 | — | — | 1 | 7.37 |
| CHEMBL62576 | — | — | 1 | 7.37 |
| CHEMBL66089 | — | — | 1 | 7.36 |
| CHEMBL302404 | — | — | 1 | 7.35 |
| CHEMBL65664 | — | — | 1 | 7.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65665 | — | IC50 | = | 28.3 | nM | 7.55 |
| CHEMBL62974 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL62342 | — | IC50 | = | 37.7 | nM | 7.42 |
| CHEMBL62524 | — | IC50 | = | 42.3 | nM | 7.37 |
| CHEMBL62576 | — | IC50 | = | 42.5 | nM | 7.37 |
| CHEMBL66089 | — | IC50 | = | 43.3 | nM | 7.36 |
| CHEMBL302404 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL65664 | — | IC50 | = | 70.9 | nM | 7.15 |