Assay Detail
Functional
CHEMBL645542
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Evaluated in vitro for the inhibition of Aldose reductase.
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL3081) ↗| Type | SINGLE PROTEIN |
| Organism | Bos taurus |
Publication
Synthesis, activity, and molecular modeling of new 2, 4-dioxo-5-(naphthylmethylene)-3-thiazolidineacetic acids and 2-thioxo analogues as potent aldose reductase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.31 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7679 | PONALRESTAT | 2.0 | 1 | 8.15 |
| CHEMBL142239 | — | — | 1 | 8.05 |
| CHEMBL358284 | — | — | 1 | 7.96 |
| CHEMBL358825 | — | — | 1 | 7.82 |
| CHEMBL142701 | — | — | 1 | 7.70 |
| CHEMBL142001 | — | — | 1 | 7.32 |
| CHEMBL336874 | — | — | 1 | 7.29 |
| CHEMBL143658 | — | — | 1 | 7.17 |
| CHEMBL143933 | — | — | 1 | 7.10 |
| CHEMBL142615 | — | — | 1 | 7.02 |
| CHEMBL142869 | — | — | 1 | 7.00 |
| CHEMBL142390 | — | — | 1 | 6.89 |
| CHEMBL345945 | — | — | 1 | 6.82 |
| CHEMBL139720 | — | — | 1 | 6.82 |
| CHEMBL142385 | — | — | 1 | 6.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7679 | PONALRESTAT | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL142239 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL358284 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL358825 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL142701 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL142001 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL336874 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL143658 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL143933 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL142615 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL142869 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL142390 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL345945 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL139720 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL142385 | — | IC50 | = | 269.0 | nM | 6.57 |