Assay Detail
Binding
CHEMBL645555
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Displacement of [3H]prazosin from rat cortex Alpha-1 adrenergic receptor
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Design, synthesis, and structure-activity relationships of a new series of alpha-adrenergic agonists: spiro[(1,3-diazacyclopent-1-ene)-5,2'-(1',2',3',4'- tetrahydronaphthalene)].
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 5.43 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL131539 | — | — | 1 | 6.22 |
| CHEMBL130784 | — | — | 1 | 6.22 |
| CHEMBL338683 | — | — | 1 | 6.16 |
| CHEMBL133231 | — | — | 1 | 6.10 |
| CHEMBL98471 | — | — | 1 | 6.00 |
| CHEMBL336331 | — | — | 1 | 5.70 |
| CHEMBL131220 | — | — | 1 | 5.60 |
| CHEMBL336332 | — | — | 1 | 5.47 |
| CHEMBL130853 | — | — | 1 | 4.84 |
| CHEMBL133579 | — | — | 1 | 4.80 |
| CHEMBL131417 | — | — | 1 | 4.80 |
| CHEMBL336970 | — | — | 1 | 4.53 |
| CHEMBL101340 | — | — | 1 | 4.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL131539 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL130784 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL338683 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL133231 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL98471 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL336331 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL131220 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL336332 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL130853 | — | Ki | = | 14400.0 | nM | 4.84 |
| CHEMBL133579 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL131417 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL336970 | — | Ki | = | 29400.0 | nM | 4.53 |
| CHEMBL101340 | — | Ki | = | 65800.0 | nM | 4.18 |