Assay Detail
Binding
CHEMBL645558
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Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]prazosin binding in rat brain
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
(1,4-Benzothiazinyloxy)alkylpiperazine derivatives as potential antihypertensive agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 7.45 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL143463 | — | — | 1 | 8.89 |
| CHEMBL142948 | — | — | 1 | 8.08 |
| CHEMBL140477 | — | — | 1 | 7.85 |
| CHEMBL141194 | — | — | 1 | 7.82 |
| CHEMBL142474 | — | — | 1 | 7.80 |
| CHEMBL143944 | — | — | 1 | 7.70 |
| CHEMBL143288 | — | — | 1 | 7.64 |
| CHEMBL341723 | — | — | 1 | 7.64 |
| CHEMBL341614 | — | — | 1 | 7.57 |
| CHEMBL143397 | — | — | 1 | 7.42 |
| CHEMBL142635 | NAFTOPIDIL | 4.0 | 1 | 7.41 |
| CHEMBL142995 | — | — | 1 | 7.22 |
| CHEMBL142859 | — | — | 1 | 7.14 |
| CHEMBL143608 | — | — | 1 | 7.05 |
| CHEMBL143923 | — | — | 1 | 6.27 |
| CHEMBL143679 | — | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL143463 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL142948 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL140477 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL141194 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL142474 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL143944 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL143288 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL341723 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL341614 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL143397 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL142635 | NAFTOPIDIL | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL142995 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL142859 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL143608 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL143923 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL143679 | — | Ki | = | 2400.0 | nM | 5.62 |