Assay Detail
Binding
CHEMBL645561
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Binding affinity against Alpha-1 adrenergic receptor from rat cerebral cortex
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Orally active benzamide antipsychotic agents with affinity for dopamine D2, serotonin 5-HT1A, and adrenergic alpha1 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 45 | 7.94 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL292107 | — | — | 1 | 8.92 |
| CHEMBL291846 | — | — | 1 | 8.92 |
| CHEMBL10085 | MAZAPERTINE | 2.0 | 1 | 8.89 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 8.85 |
| CHEMBL61440 | — | — | 1 | 8.77 |
| CHEMBL441795 | — | — | 1 | 8.72 |
| CHEMBL303982 | — | — | 1 | 8.72 |
| CHEMBL64702 | — | — | 1 | 8.68 |
| CHEMBL62150 | — | — | 1 | 8.68 |
| CHEMBL64528 | — | — | 1 | 8.66 |
| CHEMBL60122 | — | — | 1 | 8.64 |
| CHEMBL413546 | — | — | 1 | 8.48 |
| CHEMBL59167 | — | — | 1 | 8.48 |
| CHEMBL60411 | — | — | 1 | 8.47 |
| CHEMBL64227 | — | — | 1 | 8.36 |
| CHEMBL64274 | — | — | 1 | 8.33 |
| CHEMBL60675 | — | — | 1 | 8.22 |
| CHEMBL279837 | — | — | 1 | 8.19 |
| CHEMBL301465 | — | — | 1 | 8.17 |
| CHEMBL428175 | RWJ-25730 | — | 1 | 8.09 |
| CHEMBL59855 | — | — | 1 | 8.09 |
| CHEMBL61926 | — | — | 1 | 7.96 |
| CHEMBL60110 | — | — | 1 | 7.94 |
| CHEMBL61117 | — | — | 1 | 7.94 |
| CHEMBL61816 | — | — | 1 | 7.89 |
| CHEMBL294129 | — | — | 1 | 7.80 |
| CHEMBL292752 | — | — | 1 | 7.80 |
| CHEMBL62024 | — | — | 1 | 7.72 |
| CHEMBL293658 | — | — | 1 | 7.68 |
| CHEMBL64210 | — | — | 1 | 7.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL292107 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL291846 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL10085 | MAZAPERTINE | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL42 | CLOZAPINE | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL61440 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL441795 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL303982 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL64702 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL62150 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL64528 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL60122 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL59167 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL413546 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL60411 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL64227 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL64274 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL60675 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL279837 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL301465 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL428175 | RWJ-25730 | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL59855 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL61926 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL60110 | — | Ki | = | 11.4 | nM | 7.94 |
| CHEMBL61117 | — | Ki | = | 11.4 | nM | 7.94 |
| CHEMBL61816 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL294129 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL292752 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL62024 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL293658 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL64210 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL304435 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL417402 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL59853 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL58299 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL61478 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL61975 | — | Ki | = | 284.0 | nM | 6.55 |
| CHEMBL61963 | — | Ki | = | 388.0 | nM | 6.41 |
| CHEMBL64226 | — | Ki | = | 486.0 | nM | 6.31 |
| CHEMBL64547 | — | Ki | = | 486.0 | nM | 6.31 |
| CHEMBL61470 | — | Ki | = | 562.0 | nM | 6.25 |
| CHEMBL59801 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL60313 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL294409 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL64678 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL59954 | — | Ki | > | 1000.0 | nM | - |