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Assay Detail

CHEMBL645563

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Binding
Compound was evaluated for its binding affinity against alpha-1 adrenergic receptors
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Adrenergic receptor alpha-1 (CHEMBL1907610)
Type PROTEIN FAMILY
Organism Rattus norvegicus

Publication

Discovery of nanomolar ligands for 7-transmembrane G-protein-coupled receptors from a diverse N-(substituted)glycine peptoid library.
Zuckermann RN, Martin EJ, Spellmeyer DC, Stauber GB, Shoemaker KR, Kerr JM, Figliozzi GM, Goff DA, Siani MA, Simon RJ.
J Med Chem (1994) 37 : 2678 -2685
PubMed 8064796 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 2 6.68 6.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL92380 1 6.85
CHEMBL92379 1 6.51

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL92380 Ki = 140.0 nM 6.85
CHEMBL92379 Ki = 310.0 nM 6.51