Assay Detail
Binding
CHEMBL645565
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In vitro binding affinity at human Alpha-1B adrenergic receptor.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New pyrimido[5,4-b]indoles as ligands for alpha(1)-adrenoceptor subtypes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 6.95 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301707 | — | — | 1 | 8.74 |
| CHEMBL57163 | — | — | 1 | 8.59 |
| CHEMBL99761 | — | — | 1 | 8.54 |
| CHEMBL99879 | — | — | 1 | 7.93 |
| CHEMBL433203 | — | — | 1 | 7.86 |
| CHEMBL317555 | — | — | 1 | 7.84 |
| CHEMBL99142 | — | — | 1 | 7.68 |
| CHEMBL316677 | — | — | 1 | 7.57 |
| CHEMBL99979 | — | — | 1 | 7.56 |
| CHEMBL433014 | — | — | 1 | 7.21 |
| CHEMBL98807 | — | — | 1 | 6.79 |
| CHEMBL329971 | — | — | 1 | 6.61 |
| CHEMBL317556 | — | — | 1 | 5.69 |
| CHEMBL100481 | — | — | 1 | 5.39 |
| CHEMBL95605 | — | — | 1 | 5.11 |
| CHEMBL100434 | — | — | 1 | 5.02 |
| CHEMBL95986 | — | — | 1 | 4.00 |
| CHEMBL99994 | — | — | 1 | - |
| CHEMBL319345 | — | — | 1 | - |
| CHEMBL98912 | — | — | 1 | - |
| CHEMBL99363 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301707 | — | Ki | = | 1.82 | nM | 8.74 |
| CHEMBL57163 | — | Ki | = | 2.57 | nM | 8.59 |
| CHEMBL99761 | — | Ki | = | 2.884 | nM | 8.54 |
| CHEMBL99879 | — | Ki | = | 11.75 | nM | 7.93 |
| CHEMBL433203 | — | Ki | = | 13.8 | nM | 7.86 |
| CHEMBL317555 | — | Ki | = | 14.45 | nM | 7.84 |
| CHEMBL99142 | — | Ki | = | 20.89 | nM | 7.68 |
| CHEMBL316677 | — | Ki | = | 26.92 | nM | 7.57 |
| CHEMBL99979 | — | Ki | = | 27.54 | nM | 7.56 |
| CHEMBL433014 | — | Ki | = | 61.66 | nM | 7.21 |
| CHEMBL98807 | — | Ki | = | 162.18 | nM | 6.79 |
| CHEMBL329971 | — | Ki | = | 245.47 | nM | 6.61 |
| CHEMBL317556 | — | Ki | = | 2041.74 | nM | 5.69 |
| CHEMBL100481 | — | Ki | = | 4073.8 | nM | 5.39 |
| CHEMBL95605 | — | Ki | = | 7762.47 | nM | 5.11 |
| CHEMBL100434 | — | Ki | = | 9549.93 | nM | 5.02 |
| CHEMBL95986 | — | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL99994 | — | Ki | < | 10000.0 | nM | - |
| CHEMBL319345 | — | Ki | = | 55.0 | nM | - |
| CHEMBL98912 | — | Ki | < | 10000.0 | nM | - |
| CHEMBL99363 | — | Ki | < | 10000.0 | nM | - |