Assay Detail
Binding
CHEMBL645567
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Binding affinity was tested on human Alpha-1B adrenergic receptor
32
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Pharmacological options in the treatment of benign prostatic hyperplasia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 32 | 7.58 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 9.60 |
| CHEMBL707 | DOXAZOSIN | 4.0 | 1 | 9.00 |
| CHEMBL836 | TAMSULOSIN | 4.0 | 3 | 8.90 |
| CHEMBL25300 | — | — | 1 | 8.90 |
| CHEMBL25554 | — | — | 1 | 8.60 |
| CHEMBL611 | TERAZOSIN | 4.0 | 1 | 8.60 |
| CHEMBL709 | ALFUZOSIN | 4.0 | 1 | 8.00 |
| CHEMBL24981 | — | — | 1 | 7.90 |
| CHEMBL5483012 | — | — | 2 | 7.87 |
| CHEMBL267336 | — | — | 1 | 7.80 |
| CHEMBL88272 | — | — | 1 | 7.80 |
| CHEMBL25467 | — | — | 1 | 7.70 |
| CHEMBL24778 | SILODOSIN | 4.0 | 1 | 7.70 |
| CHEMBL2051956 | DEXNIGULDIPINE | 2.0 | 2 | 7.60 |
| CHEMBL278865 | UPIDOSIN | 2.0 | 1 | 7.50 |
| CHEMBL420060 | — | — | 1 | 7.40 |
| CHEMBL282214 | — | — | 1 | 7.40 |
| CHEMBL279516 | INDORAMIN | 2.0 | 1 | 7.40 |
| CHEMBL284470 | — | — | 1 | 7.19 |
| CHEMBL24777 | — | — | 1 | 7.10 |
| CHEMBL25121 | — | — | 1 | 6.83 |
| CHEMBL27899 | — | — | 1 | 6.76 |
| CHEMBL286591 | — | — | 1 | 6.70 |
| CHEMBL276932 | — | — | 1 | 6.55 |
| CHEMBL180932 | — | — | 1 | 6.49 |
| CHEMBL180561 | — | — | 1 | 6.48 |
| CHEMBL284103 | — | — | 1 | 6.38 |
| CHEMBL543741 | — | — | 1 | 6.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2 | PRAZOSIN | Ki | = | 0.2512 | nM | 9.60 |
| CHEMBL707 | DOXAZOSIN | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL836 | TAMSULOSIN | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL836 | TAMSULOSIN | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL25300 | — | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL25554 | — | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL611 | TERAZOSIN | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL709 | ALFUZOSIN | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL24981 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL5483012 | — | Ki | = | 13.49 | nM | 7.87 |
| CHEMBL88272 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL267336 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL25467 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL24778 | SILODOSIN | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL2051956 | DEXNIGULDIPINE | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL278865 | UPIDOSIN | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL282214 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL279516 | INDORAMIN | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL420060 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL2051956 | DEXNIGULDIPINE | Ki | = | 54.95 | nM | 7.26 |
| CHEMBL284470 | — | Ki | = | 64.57 | nM | 7.19 |
| CHEMBL24777 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL836 | TAMSULOSIN | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL5483012 | — | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL25121 | — | Ki | = | 147.91 | nM | 6.83 |
| CHEMBL27899 | — | Ki | = | 173.78 | nM | 6.76 |
| CHEMBL286591 | — | Ki | = | 199.53 | nM | 6.70 |
| CHEMBL276932 | — | Ki | = | 281.84 | nM | 6.55 |
| CHEMBL180932 | — | Ki | = | 323.59 | nM | 6.49 |
| CHEMBL180561 | — | Ki | = | 331.13 | nM | 6.48 |
| CHEMBL284103 | — | Ki | = | 416.87 | nM | 6.38 |
| CHEMBL543741 | — | Ki | = | 630.96 | nM | 6.20 |