Assay Detail
Binding
CHEMBL645569
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Binding affinity measured in CHO cells expressing human cloned Alpha-1B adrenergic receptor expressed as pKi
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Prazosin-related compounds. Effect of transforming the piperazinylquinazoline moiety into an aminomethyltetrahydroacridine system on the affinity for alpha1-adrenoreceptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.42 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL143026 | — | — | 1 | 8.05 |
| CHEMBL25554 | — | — | 1 | 8.00 |
| CHEMBL2112853 | — | — | 1 | 7.90 |
| CHEMBL143558 | — | — | 1 | 7.40 |
| CHEMBL144779 | — | — | 1 | 6.66 |
| CHEMBL145793 | — | — | 1 | 6.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL143026 | — | Ki | = | 8.913 | nM | 8.05 |
| CHEMBL25554 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL2112853 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL143558 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL144779 | — | Ki | = | 218.78 | nM | 6.66 |
| CHEMBL145793 | — | Ki | = | 295.12 | nM | 6.53 |