Assay Detail
Binding
CHEMBL645573
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Binding affinity determined by displacement of [3H]prazosin from alpha-1B adrenergic receptor
28
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Identification of a dihydropyridine as a potent alpha1a adrenoceptor-selective antagonist that inhibits phenylephrine-induced contraction of the human prostate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 6.71 | 8.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL611 | TERAZOSIN | 4.0 | 1 | 8.71 |
| CHEMBL91022 | — | — | 1 | 7.87 |
| CHEMBL327931 | — | — | 1 | 7.38 |
| CHEMBL91956 | — | — | 1 | 7.11 |
| CHEMBL327712 | — | — | 1 | 6.94 |
| CHEMBL314960 | — | — | 1 | 6.91 |
| CHEMBL284470 | — | — | 1 | 6.87 |
| CHEMBL92322 | — | — | 1 | 6.86 |
| CHEMBL89243 | — | — | 1 | 6.82 |
| CHEMBL313160 | — | — | 1 | 6.79 |
| CHEMBL313953 | — | — | 1 | 6.79 |
| CHEMBL327775 | — | — | 1 | 6.78 |
| CHEMBL315538 | — | — | 1 | 6.69 |
| CHEMBL5483012 | — | — | 1 | 6.66 |
| CHEMBL91415 | — | — | 1 | 6.65 |
| CHEMBL88448 | — | — | 1 | 6.62 |
| CHEMBL91550 | — | — | 1 | 6.61 |
| CHEMBL89685 | — | — | 1 | 6.58 |
| CHEMBL315914 | — | — | 1 | 6.57 |
| CHEMBL279436 | — | — | 3 | 6.48 |
| CHEMBL88388 | — | — | 1 | 6.42 |
| CHEMBL284103 | — | — | 1 | 6.31 |
| CHEMBL313251 | — | — | 1 | 6.01 |
| CHEMBL312871 | — | — | 1 | 5.93 |
| CHEMBL315392 | — | — | 1 | 5.93 |
| CHEMBL88628 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL611 | TERAZOSIN | Ki | = | 1.95 | nM | 8.71 |
| CHEMBL91022 | — | Ki | = | 13.49 | nM | 7.87 |
| CHEMBL327931 | — | Ki | = | 41.69 | nM | 7.38 |
| CHEMBL91956 | — | Ki | = | 77.62 | nM | 7.11 |
| CHEMBL327712 | — | Ki | = | 114.82 | nM | 6.94 |
| CHEMBL314960 | — | Ki | = | 123.03 | nM | 6.91 |
| CHEMBL284470 | — | Ki | = | 134.9 | nM | 6.87 |
| CHEMBL92322 | — | Ki | = | 138.04 | nM | 6.86 |
| CHEMBL89243 | — | Ki | = | 151.36 | nM | 6.82 |
| CHEMBL313160 | — | Ki | = | 162.18 | nM | 6.79 |
| CHEMBL313953 | — | Ki | = | 162.18 | nM | 6.79 |
| CHEMBL327775 | — | Ki | = | 165.96 | nM | 6.78 |
| CHEMBL315538 | — | Ki | = | 204.17 | nM | 6.69 |
| CHEMBL5483012 | — | Ki | = | 218.78 | nM | 6.66 |
| CHEMBL91415 | — | Ki | = | 223.87 | nM | 6.65 |
| CHEMBL88448 | — | Ki | = | 239.88 | nM | 6.62 |
| CHEMBL91550 | — | Ki | = | 245.47 | nM | 6.61 |
| CHEMBL89685 | — | Ki | = | 263.03 | nM | 6.58 |
| CHEMBL315914 | — | Ki | = | 269.15 | nM | 6.57 |
| CHEMBL279436 | — | Ki | = | 331.13 | nM | 6.48 |
| CHEMBL279436 | — | Ki | = | 363.08 | nM | 6.44 |
| CHEMBL88388 | — | Ki | = | 380.19 | nM | 6.42 |
| CHEMBL279436 | — | Ki | = | 446.68 | nM | 6.35 |
| CHEMBL284103 | — | Ki | = | 489.78 | nM | 6.31 |
| CHEMBL313251 | — | Ki | = | 977.24 | nM | 6.01 |
| CHEMBL315392 | — | Ki | = | 1174.9 | nM | 5.93 |
| CHEMBL312871 | — | Ki | = | 1174.9 | nM | 5.93 |
| CHEMBL88628 | — | Ki | = | 1778.28 | nM | 5.75 |