Assay Detail
Binding
CHEMBL645607
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Binding affinity for Alpha-2 adrenergic receptor of CHO-C10 membrane preparation
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cricetulus griseus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Analogs of UK 14,304: Structural features responsible for 2 adrenoceptor activity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.98 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50390 | — | — | 1 | 9.60 |
| CHEMBL298936 | — | — | 1 | 8.92 |
| CHEMBL49137 | — | — | 1 | 8.89 |
| CHEMBL844 | BRIMONIDINE | 4.0 | 1 | 8.62 |
| CHEMBL42139 | — | — | 1 | 8.51 |
| CHEMBL50769 | — | — | 1 | 8.28 |
| CHEMBL50430 | — | — | 1 | 8.11 |
| CHEMBL49284 | — | — | 1 | 8.02 |
| CHEMBL49395 | — | — | 1 | 7.39 |
| CHEMBL883 | — | — | 1 | 7.39 |
| CHEMBL298124 | — | — | 1 | 6.75 |
| CHEMBL300073 | — | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50390 | — | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL298936 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL49137 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL844 | BRIMONIDINE | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL42139 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL50769 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL50430 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL49284 | — | Ki | = | 9.6 | nM | 8.02 |
| CHEMBL49395 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL883 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL298124 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL300073 | — | Ki | = | 5300.0 | nM | 5.28 |