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Compound Detail

CHEMBL883

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N=C(N)Nc1ccc2nccnc2c1Br

Basic Information

ChEMBL ID CHEMBL883
Phase Preclinical
Structure Type MOL
InChI Key WBGSURPVIDDDHF-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

266.1
MW (Da)
1.70
ALogP
3
HBA
3
HBD
87.7
PSA (Ų)
0.54
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C9H8BrN5
MW 266.10
Aromatic Rings 2
Heavy Atoms 15
NP-Likeness -0.63

Activity Summary

Ki 2 meas. best 7.39

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adrenergic receptor alpha-2
CHEMBL2095158
Ki 7.39 7.39 41.0 1
Adrenergic receptor alpha-1
CHEMBL2094251
Ki 4.77 4.77 17000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1016/0960-894X(95)00295-5 Adrenergic receptor alpha-2 2
- 10.1016/0960-894X(95)00295-5 Adrenergic receptor alpha-1 1

Data from ChEMBL 36 via Core Engine