Assay Detail
Binding
CHEMBL643530
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Binding affinity for Alpha-1 adrenergic receptor of human cerebral cortex membrane
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Cerebral cortex |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Analogs of UK 14,304: Structural features responsible for 2 adrenoceptor activity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 5.51 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50390 | — | — | 1 | 6.89 |
| CHEMBL298936 | — | — | 1 | 6.33 |
| CHEMBL49137 | — | — | 1 | 5.85 |
| CHEMBL50769 | — | — | 1 | 5.82 |
| CHEMBL844 | BRIMONIDINE | 4.0 | 1 | 5.72 |
| CHEMBL42139 | — | — | 1 | 5.62 |
| CHEMBL50430 | — | — | 1 | 5.60 |
| CHEMBL49284 | — | — | 1 | 5.05 |
| CHEMBL300073 | — | — | 1 | 5.00 |
| CHEMBL49395 | — | — | 1 | 4.96 |
| CHEMBL883 | — | — | 1 | 4.77 |
| CHEMBL298124 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50390 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL298936 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL49137 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL50769 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL844 | BRIMONIDINE | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL42139 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL50430 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL49284 | — | Ki | = | 8900.0 | nM | 5.05 |
| CHEMBL300073 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL49395 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL883 | — | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL298124 | — | Ki | = | 30000.0 | nM | 4.52 |