Assay Detail
Functional
CHEMBL645667
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Conversion of [32P] ATP to [32P]-cyclic AMP mediated by adenylate cyclase 1
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Forskolin carbamates: binding and activation studies with type I adenylyl cyclase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 45 | 5.71 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL52606 | COLFORSIN | 2.0 | 1 | 6.30 |
| CHEMBL330054 | — | — | 1 | 6.30 |
| CHEMBL93009 | — | — | 1 | 6.30 |
| CHEMBL430458 | — | — | 1 | 6.30 |
| CHEMBL328561 | — | — | 1 | 6.22 |
| CHEMBL328689 | — | — | 1 | 6.22 |
| CHEMBL92719 | — | — | 1 | 6.20 |
| CHEMBL91909 | — | — | 1 | 6.16 |
| CHEMBL92229 | — | — | 1 | 6.16 |
| CHEMBL317534 | — | — | 1 | 6.00 |
| CHEMBL92857 | — | — | 1 | 5.96 |
| CHEMBL93259 | — | — | 1 | 5.96 |
| CHEMBL93242 | — | — | 1 | 5.96 |
| CHEMBL93194 | — | — | 1 | 5.92 |
| CHEMBL93521 | — | — | 1 | 5.89 |
| CHEMBL317990 | — | — | 1 | 5.85 |
| CHEMBL327672 | — | — | 1 | 5.85 |
| CHEMBL329247 | — | — | 1 | 5.82 |
| CHEMBL94168 | — | — | 1 | 5.80 |
| CHEMBL94313 | — | — | 1 | 5.77 |
| CHEMBL94343 | — | — | 1 | 5.75 |
| CHEMBL92911 | — | — | 1 | 5.70 |
| CHEMBL93408 | — | — | 1 | 5.68 |
| CHEMBL93468 | — | — | 1 | 5.68 |
| CHEMBL93042 | — | — | 1 | 5.66 |
| CHEMBL93393 | — | — | 1 | 5.62 |
| CHEMBL419139 | — | — | 1 | 5.60 |
| CHEMBL93260 | — | — | 1 | 5.57 |
| CHEMBL94135 | — | — | 1 | 5.51 |
| CHEMBL420432 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL52606 | COLFORSIN | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL430458 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL93009 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL330054 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL328561 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL328689 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL92719 | — | EC50 | = | 630.0 | nM | 6.20 |
| CHEMBL91909 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL92229 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL317534 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL92857 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL93259 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL93242 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL93194 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL93521 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL317990 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL327672 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL329247 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL94168 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL94313 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL94343 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL92911 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL93408 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL93468 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL93042 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL93393 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL419139 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL93260 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL94135 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL420432 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL432817 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL327697 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL89962 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL90423 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL329916 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL328358 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL93841 | — | EC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL330704 | — | EC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL93252 | — | EC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL92687 | — | EC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL327612 | — | EC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL92577 | — | EC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL93469 | — | EC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL91795 | — | EC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL92919 | — | EC50 | - | nM | - |